No, because to tie the main drain into one socket, and pump suction into the other socket of ParaSkim skimmer, you must use an optional Pentair float valve part 08650-0079.  That float valve covers up the bottom opening for the venturi feed line making the venturi part of the skimmer inoperable.   However, the non-Venturi version of the ParaSkim can be plumbed that way.  Paramount does not recommend this type of a main drain set up with any in-floor system.   This is because in-floor cleaning systems are designed to pull in large amounts of debris from our special debris accepting drains and that debris would get caught in the limited space between the Float assembly and the skimmer bottom.